- By sahlhealth
- May 18, 2021
- 24 views
Amyloidosis (am-uh-loi-DO-sis) is a rare disease that occurs when a substance called amyloid builds up in your organs. Amyloid is an abnormal protein that is produced in your bone marrow and can be deposited in any tissue or organ.Amyloidosis can affect different organs in different people, and there are different types of amyloid. Amyloidosis frequently affects the heart, kidneys, liver, spleen, nervous system and digestive tract. Severe Amyloidosis can lead to life-threatening organ failure.There’s no cure for Amyloidosis. But treatments can help you manage your symptoms and limit the production of amyloid protein.
-You may not experience signs and symptoms of Amyloidosis until the condition is advanced. When signs and symptoms are evident, they depend on which of your organs are affected.
Signs and symptoms may include:
- Swelling of your ankles and legs
- Severe fatigue and weakness
- Shortness of breath
- Numbness, tingling or pain in your hands or feet, especially pain in your wrist (carpal tunnel syndrome)
- Diarrhea, possibly with blood, or constipation
- Unintentional, significant weight loss
- An enlarged tongue
- Skin changes, such as thickening or easy bruising, and purplish patches around the eyes
- An irregular heartbeat
- Difficulty swallowing
When to see a doctor
-See your doctor if you persistently experience any of the signs or symptoms associated with Amyloidosis.
-There's no cure for Amyloidosis. But treatment can help manage signs and symptoms and limit further production of amyloid protein. Specific treatments depend on the type of Amyloidosis and target the source of the amyloid production.
- AL amyloidosis. Many of the same chemotherapy medications that treat multiple myeloma are used in AL Amyloidosis to stop the growth of abnormal cells that produce amyloid.
- Autologous blood stem cell transplant (ASCT) offers an additional treatment option in some cases. This procedure involves collecting your own stem cells from your blood and storing them for a short time while you have high-dose chemotherapy. The stem cells are then returned to your body via a vein.ASCT is most appropriate for people whose disease isn't advanced and whose heart isn't greatly affected.
- AA Amyloidosis. Treatments target the underlying condition â€” for example, an anti-inflammatory medication to treat rheumatoid arthritis.
- Hereditary Amyloidosis. Liver transplantation may be an option because the protein that causes this form of Amyloidosis is made in the liver.
- Dialysis-related Amyloidosis. Treatments include changing your mode of dialysis or having a kidney transplant.
-To manage ongoing signs and symptoms of Amyloidosis, your doctor also may recommend:
- Pain medication
- Fluid retention medication (diuretic) and a low-salt diet
- Blood-thinning medication
- Medication to control your heart rate