- By sahlhealth
- May 18, 2021
- 32 views
Ankylosing Spondylitis is an inflammatory disease that, over time, can cause some of the vertebrae in your spine to fuse. This fusing makes the spine less flexible and can result in a hunched-forward posture. If ribs are affected, it can be difficult to breathe deeply.Ankylosing spondylitis affects men more often than women. Signs and symptoms typically begin in early adulthood. Inflammation also can occur in other parts of your body â€” most commonly, your eyes.There is no cure for Ankylosing spondylitis, but treatments can lessen your symptoms and possibly slow progression of the disease.
-Early signs and symptoms of ankylosing spondylitis might include pain and stiffness in your lower back and hips, especially in the morning and after periods of inactivity. Neck pain and fatigue also are common. Over time, symptoms might worsen, improve or stop at irregular intervals.
The areas most commonly affected are:
- The joint between the base of your spine and your pelvis (sacroiliac)
- The vertebrae in your lower back
- The places where your tendons and ligaments attach to bones (entheses), mainly in your spine, but sometimes along the back of your heel
- The cartilage between your breastbone and ribs
- Your hip and shoulder joints
-The goal of treatment is to relieve your pain and stiffness, and prevent or delay complications and spinal deformity. Ankylosing spondylitis treatment is most successful before the disease causes irreversible damage to your joints.
- Nonsteroidal anti-inflammatory drugs (NSAIDs) â€” such as naproxen (Naprosyn) and indomethacin (Indocin) â€” are the medications doctors most commonly use to treat Ankylosing spondylitis. They can relieve your inflammation, pain and stiffness. However, these medications might cause gastrointestinal bleeding.If NSAIDs aren't helpful, your doctor might suggest starting a biologic medication, such as a tumor necrosis factor (TNF) blocker or an interleukin 17 (IL-17) inhibitor. TNF blockers target a cell protein that causes inflammation in the body. IL-17 plays a role in your body's defense against infection and also has a role in inflammation.TNF blockers help reduce pain, stiffness, and tender or swollen joints. They are administered by injecting the medication under the skin or through an intravenous line.
-The five TNF blockers approved by the Food & Drug Administration to treat Ankylosing spondylitis are:
- Adalimumab (Humira)
- Certolizumab pegol (Cimzia)
- Etanercept (Enbrel)
- Golimumab (Simponi; Simponi Aria)
- Infliximab (Remicade)
-Secukinumab (Cosentyx) is the first IL-17 inhibitor approved by the FDA for the treatment of Ankylosing spondylitis. TNF blockers and IL-17 inhibitors can reactivate latent tuberculosis and make you more prone to infection.
-Physical therapy is an important part of treatment and can provide a number of benefits, from pain relief to improved strength and flexibility. A physical therapist can design specific exercises for your needs.Range-of-motion and stretching exercises can help maintain flexibility in your joints and preserve good posture. Proper sleep and walking positions and abdominal and back exercises can help maintain your upright posture.
-Most people with Ankylosing spondylitis don't need surgery. However, your doctor might recommend surgery if you have severe pain or joint damage, or if your hip joint is so damaged that it needs to be replaced.