Restless legs syndrome
- By sahlhealth
- May 18, 2021
- 31 views
Restless legs syndrome (RLS) is a condition that causes an uncontrollable urge to move your legs, usually because of an uncomfortable sensation. It typically happens in the evening or nighttime hours when you’re sitting or lying down. Moving eases the unpleasant feeling temporarily.
Restless legs syndrome, now known as restless legs syndrome/Willis-Ekbom disease (RLS/WED), can begin at any age and generally worsens as you age. It can disrupt sleep, which interferes with daily activities.
Simple self-care steps and lifestyle changes may help you. Medications also help many people with restless legs syndrome.
The chief symptom is an urge to move the legs. Common accompanying characteristics of RLS/WED include:
- Sensations that begin after rest: The sensation typically begins after you've been lying down or sitting for an extended time, such as in a car, airplane or movie theater.
- Relief with movement: The sensation of RLS/WED lessens with movement, such as stretching, jiggling your legs, pacing or walking.
- Worsening of symptoms in the evening: Symptoms occur mainly at night.
- Nighttime leg twitching. RLS/WED may be associated with another, more common condition called periodic limb movement of sleep, which causes your legs to twitch and kick, possibly throughout the night, while you sleep.
People typically describe RLS/WED symptoms as abnormal, unpleasant sensations in their legs or feet. They usually happen on both sides of the body. Less commonly, the sensations affect the arms.
The sensations, which generally occur within the limb rather than on the skin, are described as:
Sometimes the sensations are difficult to explain. Affected people usually don't describe the condition as a muscle cramp or numbness. They do, however, consistently describe the desire to move their legs.
It's common for symptoms to fluctuate in severity. Sometimes, symptoms disappear for periods of time, then come back.
When to see a doctor
Some people with RLS/WED never seek medical attention because they worry they won't be taken seriously. But RLS/WED can interfere with your sleep and cause daytime drowsiness and affect your quality of life. Talk with your doctor if you think you may have RLS/WED
Your doctor will take your medical history and ask for a description of your symptoms. A diagnosis of RLS/WED is based on the following criteria, established by the International Restless Legs Syndrome Study Group and International Classification of Sleep Disorders:
- You have a strong, often irresistible urge to move your legs, usually accompanied by uncomfortable sensations typically described as crawling, creeping, cramping, tingling or pulling.
- Your symptoms start or get worse when you're resting, such as sitting or lying down.
- Your symptoms are partially or temporarily relieved by activity, such as walking or stretching.
- Your symptoms are worse at night.
- Symptoms can't be explained solely by another medical or behavioral condition.
Your doctor may conduct a physical and a neurological exam. Blood tests, particularly for iron deficiency, may be ordered to rule out other possible causes for your symptoms.
In addition, your doctor may refer you to a sleep specialist. This may involve an overnight stay at a sleep clinic, where doctors can study your sleep if another sleep disorder such as sleep apnea is suspected. However, a diagnosis of RLS/WED usually doesn't require a sleep study.
Sometimes, treating an underlying condition, such as iron deficiency, greatly relieves symptoms of restless legs syndrome. Correcting an iron deficiency may involve receiving iron supplementation orally or intravenously. However, take iron supplements only with medical supervision and after your doctor has checked your blood-iron level.
If you have RLS/WED without an associated condition, treatment focuses on lifestyle changes. If those aren't effective, your doctor might prescribe medications.
Several prescription medications, most of which were developed to treat other diseases, are available to reduce the restlessness in your legs. These include:
- Medications that increase dopamine in the brain: These medications affect levels of the chemical messenger dopamine in your brain. Ropinirole (Requip), rotigotine (Neupro) and pramipexole (Mirapex) are approved by the Food and Drug Administration for the treatment of moderate to severe RLS/WED. Short-term side effects of these medications are usually mild and include nausea, lightheadedness and fatigue. However, they can also cause impulse control disorders, such as compulsive gambling, and daytime sleepiness.
- Drugs affecting calcium channels: Certain medications, such as gabapentin (Neurontin), gabapentin enacarbil (Horizant) and pregabalin (Lyrica), work for some people with RLS/WED.
- Opioids: Narcotic medications can relieve mild to severe symptoms, but they may be addicting if used in high doses. Some examples include codeine, oxycodone (OxyContin, Roxicodone), combined oxycodone and acetaminophen (Percocet, Roxicet), and combined hydrocodone and acetaminophen (Norco, Vicodin).
- Muscle relaxants and sleep medications: Known as benzodiazepines, these drugs help you sleep better at night, but they don't eliminate the leg sensations, and they may cause daytime drowsiness. A commonly used sedative for RLS/WED is clonazepam (Klonopin). These drugs are generally only used if no other treatment provides relief.
It may take several trials for you and your doctor to find the right medication or combination of medications that work best for you.
Caution about medications
Sometimes dopamine medications that have worked for a while to relieve your RLS/WED become ineffective, or you notice your symptoms returning earlier in the day. This is called augmentation. Your doctor may substitute another medication to combat the problem.
Most drugs prescribed to treat RLS/WED aren't recommended during pregnancy. Instead, your doctor may recommend self-care techniques to relieve symptoms. However, if the sensations are particularly bothersome during your last trimester, your doctor may approve the use of certain drugs.
Some medications may worsen symptoms of RLS/WED. These include some antidepressants, some antipsychotic medications, some anti-nausea drugs, and some cold and allergy medications. Your doctor may recommend that you avoid these medications, if possible. However, if you need to take these medications, talk to your doctor about adding drugs to help manage your RLS/WED.
Often, there's no known cause for RLS/WED. Researchers suspect the condition may be caused by an imbalance of the brain chemical dopamine, which sends messages to control muscle movement.
Sometimes RLS/WED runs in families, especially if the condition starts before age 40. Researchers have identified sites on the chromosomes where genes for RLS/WED may be present.
Pregnancy or hormonal changes may temporarily worsen RLS/WED signs and symptoms. Some women get RLS/WED for the first time during pregnancy, especially during their last trimester. However, signs and symptoms usually disappear after delivery.
RLS/WED can develop at any age, even during childhood. The disorder is more common with increasing age and more common in women than in men.
Restless legs syndrome usually isn't related to a serious underlying medical problem. However, RLS/WED sometimes accompanies other conditions, such as:
- Peripheral neuropathy: This damage to the nerves in your hands and feet is sometimes due to chronic diseases such as diabetes and alcoholism.
- Iron deficiency: Even without anemia, iron deficiency can cause or worsen RLS/WED. If you have a history of bleeding from your stomach or bowels, experience heavy menstrual periods, or repeatedly donate blood, you may have iron deficiency.
- Kidney failure: If you have kidney failure, you may also have iron deficiency, often with anemia. When kidneys don't function properly, iron stores in your blood can decrease. This and other changes in body chemistry may cause or worsen RLS/WED.
- Spinal cord conditions: Lesions on the spinal cord have been linked to RLS/WED. Having had anesthesia to the spinal cord, such as a spinal block, also increases the risk of developing RLS/WED.
Although RLS/WED doesn't lead to other serious conditions, symptoms can range from barely bothersome to incapacitating. Many people with RLS/WED find it difficult to fall or stay asleep.
Severe RLS/WED can cause marked impairment in life quality and can result in depression. Insomnia may lead to excessive daytime drowsiness, but RLS/WED may interfere with napping.